SysRev Automaton
Systematic Reviews in 48 Hours
Transform 16+ month systematic reviews into 48 hours with a multi-agent AI system following rigorous Cochrane methodology.
The Problem
Scientific systematic reviews take 16-24 months to complete. Extremely labor-intensive manual process:
- ❌ 4,600+ articles to screen manually
- ❌ Multiple reviewers working weeks or months
- ❌ Repetitive manual data extraction
- ❌ High cost and delay to validate scientific evidence
- ❌ Inconsistencies between human reviewers
Our Solution
SysRev Automaton automates the entire systematic review process using 5 specialized agents working together, rigorously following Cochrane methodology.
From 16+ months to 48 hours, maintaining scientific quality and full PRISMA compliance.
- ✓ 5 Specialized agents: Screening, Full-Text, Extraction, Quality, Judge
- ✓ Triple screening: 2/3 or 3/3 consensus to avoid hallucinations
- ✓ Automatic extraction: Structured data in JSON/YAML
- ✓ Integrated meta-analysis: Forest plots, GRADE, heterogeneity
- ✓ 100% reproducible: Same protocol = same result
Process Flow
PICO Protocol + Systematic Search
Defines research, criteria and searches 4+ databases (PubMed, EMBASE, CENTRAL, CrossRef). Exports ~4,600 records.
Intelligent Deduplication
Algorithm removes duplicates. Result: ~3,500 unique articles.
Level 1 Screening (Triple Title)
3 independent agents analyze ONLY the title. 2/3 or 3/3 consensus. Approves ~800-1,000 titles (30-35%).
Level 2 Screening (Title + Abstract)
Agent analyzes title + abstract of approved items. Result: ~250-300 for full text.
Level 3 Screening (Full Text)
Agent reads full text. Judge resolves conflicts. Result: ~20 included studies.
Data Extraction + Meta-analysis
Agent extracts data. System generates meta-analysis, forest plots, GRADE assessment.
Complete PRISMA Report
PRISMA diagram, full report, plain language summary. Review ready for publication.
Performance Metrics
Screening Sensitivity
Specificity
Time Reduction
Estimated Cost per Review
vs. $50k+ in traditional human-hours
Project Status
Innovative Concept
This project represents the cutting edge of scientific automation. We apply AI rigorously, maintaining equivalent or superior Cochrane quality while reducing time from 16+ months to 48 hours. Global impact potential: accelerating medical research and democratizing access to high-quality systematic reviews.